collagen type-5

Function

• type 5 collagen is a member of group 1 collagen (fibrillar forming collagen)
• it is a minor connective tissue component of nearly ubiquitous distribution
• type 5 collagen binds to DNA, heparan sulfate, thrombospondin, heparin, & insulin
• type 5 collagen is a key determinant in the assembly of tissue-specific matrices (putative)
• associates with type-1 collagen
• may provide inner core for large collagen fibers

Structure

• Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains
• trimers of two COL5A1 & one COL5A2 chains in most tissues
• trimers of one COL5A1, oneCOL5A2, & one COL5A3 in placenta

Compartment

• found between basement membrane & interstitium

Expression

• most interstitial tissue
• placenta

More general terms

• collagen