collagen 5 alpha-2 (COL5A2)
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Function
- type 5 collagen is a member of group 1 collagen (fibrillar forming collagen)
- it is a minor connective tissue component of nearly ubiquitous distribution
- type 5 collagen binds to DNA, heparan sulfate, thrombospondin, heparin, & insulin
- type 5 collagen is a key determinant in the assembly of tissue-specific matrices (putative)
- Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains
- trimers of two COL5A1 & one COL5A2 chains in most tissues
- trimers of one COL5A1, oneCOL5A2, & one COL5A3 in placenta
Structure
- belongs to the fibrillar collagen family
- contains 1 fibrillar collagen NC1 domain
- contains 1 VWFC domain
Compartment
Pathology
- defects in COL5A2 are a cause of
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P05997.html
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/COL5A2
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 906
- ↑ OMIM https://mirror.omim.org/entry/120190
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1290
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1290
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1290
- OMIM: https://mirror.omim.org/entry/120190
- OMIM: https://mirror.omim.org/entry/130000
- OMIM: https://mirror.omim.org/entry/130010
- UniProt: http://www.uniprot.org/uniprot/P05997.html