interstitium

Introduction

Anatomical space bounded by the basement membranes of epithelial & endothelial cells. Proposed to be previously unrecognized human organ

Function

• shock absorption*

* found in tissues subject to intermittent or rhythmic compression, including: submucosa of gastrointestinal tract & urinary bladder, bile ducts, dermis, bronchial tree, musculoskeletal tissue, adipose tissue & fascia

Structure

• consists of fluid-filled spaces supported by thick collagen bundles
• fibroblast-like cells that stain with endothelial markers & vimentin line the collagen bundles
• at least some fibroblast-like cells are CD34(+)
• unusual & extensive unlined interface between the collagen bundles & the surrounding fluid.

Pathology

• potential role in cancer metastases
• potential role in edema & fibrosis

More general terms

• organ

Additional terms

• interstitial lung disease; diffuse parenchymal lung disease (DPLS, ILD)