very late antigen 5 (VLA-5, integrin alpha-5/beta-1)

Function

• receptor for fibronectin & fibrinogen
• the major fibronectin receptor on most cells
• recognizes the sequence R-G-D in its ligands

Subunits

integrin alpha-5, integrin beta-1

Pathology

• in case of HIV-1 infection, interaction with extracellular viral Tat protein seems to enhance angiogenesis in lesions of Kaposi's sarcoma

More general terms

• CD49 or Very Late Antigen (VLA)

Additional terms

• fibronectin; FN; cold-insoluble globulin; CIG; contains: anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3 (FN1, FN)