fibrinogen; coagulation factor-1

Function

• clot structural protein, gels to form clot; (distinguish from factor I (i)).

Structure

• subunits:
  • fibrinogen alpha
  • fibrinogen beta
  • fibrinogen gamma

Physiology

• selective cleavage of Arg-|-Gly bonds in fibrinogen by thrombin forms fibrin & releases fibrinopeptide A & fibrinopeptide B

Laboratory

• fibrinogen in plasma
• fibrinogen fragments in plasma
• fibrinogen fragments in urine

More general terms

• coagulation factor
• protein precursor
• multisubunit protein
• glycoprotein

More specific terms

• cryofibrinogen
• fibrinogen concentrate (RiaSTAP)
• fibrinogen variant

Additional terms

• coagulation cascade
• fibrin
• fibrinogen in plasma
• fibrinogen-like protein 1; HP-041; hepassocin; hepatocyte-derived fibrinogen-related protein 1; HFREP-1; liver fibrinogen-related protein 1; LFIRE-1 (FGL1 HFREP1)

Component of

• calcium chloride/fibrinogen/fibrinolytic inhibitor/thrombin
• fibrinogen/thrombin
• fibrinogen concentrate/thrombin; fibrin sealant (Raplixa)