thrombospondin-2 (THBS2, TSP2)

Function

• adhesive glycoprotein
• mediates cell-to-cell & cell-to-matrix interactions
• ligand for CD36 mediating antiangiogenic properties
• interacts (via the TSP type I repeats) with CD36
  • the interaction conveys an antiangiogenic effect
• interacts (via the TSP type I repeats) with HRG
  • the interaction blocks the antiangiogenic effect of THBS2 with CD36 (putative)
• can bind to fibrinogen, fibronectin, laminin & type 5 collagen

Structure

• homotrimer; disulfide-linked
• belongs to the thrombospondin family
• contains 3 EGF-like domains
• contains 1 TSP C-terminal (TSPC) domain
• contains 1 TSP N-terminal (TSPN) domain
• contains 3 TSP type-1 domains
• contains 8 TSP type-3 repeats
• contains 1 VWFC domain

Expression

• high expression in invertebral disk tissue

Pathology

• polymorphisms in THBS2 may be a cause of susceptibility to lumbar disc herniation

More general terms

• thrombospondin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7058
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7058
• OMIM: https://mirror.omim.org/entry/188061
• OMIM: https://mirror.omim.org/entry/603932
• UniProt: http://www.uniprot.org/uniprot/P35442.html