A disintegrin & metalloproteinase domain 23; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 3; MDC-3 (ADAM23, MDC3)

Function

• may play a role in cell-cell & cell-matrix interactions
• non-catalytic metalloprotease-like protein
• ligand for integrin alpha-V/beta-3

Structure

• conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor
• contains 1 disintegrin domain
• contains 1 EGF-like domain
• contains 1 peptidase M12B domain

Compartment

• cell membrane
• isoform gamma: secreted

Alternative splicing

named isoforms=3; alpha, beta, gamma

Expression

• highly expressed in brain
• weakly expressed in heart
• in the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex & occipital pole
• highly expressed in the fetal brain

More general terms

• ADAM protease
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8745
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8745
• OMIM: https://mirror.omim.org/entry/603710
• UniProt: http://www.uniprot.org/uniprot/O75077.html