ADAM (A disintegrin & metalloproteinase domain); MDC (metalloproteinase, disintegrin, cysteine-rich) protein
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Introduction
Family of cell surface proteins with both potential adhesion domain & protease domain.
Function
- cell adhesion
- sperm-egg fusion (ADAM1 & ADAM2)
- myoblast fusion (ADAM12)
- ectodomain shedding of cell surface proteins (ADAM9, ADAM10, ADAM17)
- activation of Notch (ADAM17)
- alpha-secretase activity in Alzheimer's disease (ADAM10, ADAM17)
- axon guidance
Structure
- family of cell surface proteins with both potential adhesion domain & protease domain
- cysteine rich region & EGF domain thought to mediate cell fusion or interaction with other proteins such as chaperone proteins
- ~1/2 of ADAM proteins have metalloproteinase domain that contains a catalytic consensus sequence
Compartment
Expression
- ADAM9, ADAM10, ADAM12, ADAM15, ADAM17 & ADAM19 show widespread expression
- ADAM8 & ADAM28 are predominantly hematopoietic.
- 17 ADAMs are found in CNS.
- ADAM22 & ADAM23 are predominantly found in brain
- IL1 induces transcription of some ADAMs
More general terms
More specific terms
- A disintegrin & metalloproteinase domain 1 (ADAM1, ADAMDEC1)
- A disintegrin & metalloproteinase domain 2; fertilin beta; PH-30; PH30; PH30-beta; cancer/testis antigen 15; CT15 (ADAM2 FTNB)
- A disintegrin & metalloproteinase domain 3A; cyritestin 1 (ADAM3A)
- A disintegrin & metalloproteinase domain 3B; cyritestin 2 (ADAM3B)
- A disintegrin & metalloproteinase domain 4 (ADAM4)
- A disintegrin & metalloproteinase domain 5 (ADAM5)
- A disintegrin & metalloproteinase domain 6 (ADAM6)
- A disintegrin & metalloproteinase domain 8 (ADAM8), CD156 or cell surface antigen MS2
- A disintegrin & metalloproteinase domain 9; metalloprotease/disintegrin/cysteine-rich protein 9; myeloma cell metalloproteinase; meltrin gamma (ADAM9, KIAA0021, MCMP, MDC9, MLTNG)
- A disintegrin & metalloproteinase domain 10; Kuzbanian protein homolog; mammalian disintegrin-metalloprotease; CDw156; CD156c (ADAM10, KUZ, MADM)
- A disintegrin & metalloproteinase domain 11; metalloproteinase-like, disintegrin-like, & cysteine-rich protein (ADAM11, MDC)
- A disintegrin & metalloproteinase domain 12; meltrin alpha (ADAM12, MLTN, UNQ346/PRO545)
- A disintegrin & metalloproteinase domain 13 (ADAM13)
- A disintegrin & metalloproteinase domain 14 (ADAM14)
- A disintegrin & metalloproteinase domain 15; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 15; MDC-15; metalloprotease RGD disintegrin protein; metargidin (ADAM15, MDC15)
- A disintegrin & metalloproteinase domain 16 (ADAM16)
- A disintegrin & metalloproteinase domain 17 (ADAM17), tumor necrosis factor alpha converting enzyme (TACE) or CD156b
- A disintegrin & metalloproteinase domain 18; transmembrane metalloproteinase-like, disintegrin-like, & cysteine-rich protein III; tMDC III (ADAM18, TMDC3, UNQ858/PRO1867)
- A disintegrin & metalloproteinase domain 19; meltrin-beta; metalloprotease & disintegrin dendritic antigen marker; MADDAM (ADAM19, MLTNB, FKSG34)
- A disintegrin & metalloproteinase domain 20 (ADAM20)
- A disintegrin & metalloproteinase domain 21 (ADAM21)
- A disintegrin & metalloproteinase domain 22; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 2; metalloproteinase-disintegrin ADAM22-3 (ADAM22, MDC2)
- A disintegrin & metalloproteinase domain 23; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 3; MDC-3 (ADAM23, MDC3)
- A disintegrin & metalloproteinase domain 24 (ADAM24)
- A disintegrin & metalloproteinase domain 25 (ADAM25)
- A disintegrin & metalloproteinase domain 26 (ADAM26)
- A disintegrin & metalloproteinase domain 28; metalloproteinase-like, disintegrin-like, & cysteine-rich protein-L; MDC-L; eMDC II (ADAM28, ADAM23, MDCL)
- A disintegrin & metalloproteinase domain 29; cancer/testis antigen 73; CT73 (ADAM29)
- A disintegrin & metalloproteinase domain 30 (ADAM30)
- A disintegrin & metalloproteinase domain 32 (ADAM32)
- A disintegrin & metalloproteinase domain 33 (ADAM33)
- A disintegrin & metalloproteinase domain-containing protein 7; ADAM 7; sperm maturation-related glycoprotein GP-83 (ADAM7, GP83)
- disintegrin & metalloproteinase domain-containing protein 5; transmembrane metalloproteinase-like, disintegrin-like, & cysteine-rich protein II; tMDC II (ADAM5P, TMDC2)
Additional terms
References
- ↑ Yong VW et al Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat Rev Neurosci. 2005 Dec;6(12):931-44. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16288297
- ↑ Yong VW et al Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci. 2001 Jul;2(7):502-11. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11433375
- ↑ Blobel CW ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15688065