A disintegrin & metalloproteinase domain 22; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 2; metalloproteinase-disintegrin ADAM22-3 (ADAM22, MDC2)
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Function
- probable ligand for integrin in the brain
- non catalytic metalloprotease-like protein
- role in regulation of cell adhesion & spreading & in inhibition of cell proliferation
- interacts through its C-terminal region with YWHAB & YWHAZ (14-3-3 proteins) but not with YWHAE or YWHAH
- the precursor is cleaved by a furin endopeptidase
Structure
- contains 1 disintegrin domain
- contains 1 EGF-like domain
- contains 1 peptidase M12B domain
Compartment
membrane
Alternative splicing
named isoforms=5
Expression
- highly expressed in the brain
- detected slightly or not at all in other tissues
Pathology
- expressed in some high-grade but not low-grade gliomas
Notes
- may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay