A disintegrin & metalloproteinase domain 22; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 2; metalloproteinase-disintegrin ADAM22-3 (ADAM22, MDC2)

Function

• probable ligand for integrin in the brain
• non catalytic metalloprotease-like protein
• role in regulation of cell adhesion & spreading & in inhibition of cell proliferation
• interacts through its C-terminal region with YWHAB & YWHAZ (14-3-3 proteins) but not with YWHAE or YWHAH
• the precursor is cleaved by a furin endopeptidase
• biomarker of brain aging (negative correlation)

Structure

• contains 1 disintegrin domain
• contains 1 EGF-like domain
• contains 1 peptidase M12B domain

Compartment

membrane

Alternative splicing

named isoforms=5

Expression

• highly expressed in the brain
• detected slightly or not at all in other tissues

Pathology

• expressed in some high-grade but not low-grade gliomas

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• ADAM protease
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53616
• OMIM: https://mirror.omim.org/entry/603709
• UniProt: http://www.uniprot.org/uniprot/Q9P0K1.html