14-3-3 protein epsilon; 14-3-3E (YWHAE)

Function

• adapter protein implicated in regulation of both general & specialized signaling pathways
• binds to many protein, usually by recognition of a phospho-Ser or phosphotThr motif
• binding generally results in modulation of the activity of the binding partner
• interacts with NDEL1, RGNEF & TIAM2

Structure

• homodimer
• belongs to the 14-3-3 family

Compartment

cytoplasm, melanosome

More general terms

• 14-3-3 protein (KCIP-1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7531
• OMIM: https://mirror.omim.org/entry/605066
• UniProt: http://www.uniprot.org/uniprot/P62258.html