14-3-3 protein eta; protein AS1 (YWHAH YWHA1)

Function

• adapter protein implicated in regulationboth general & specialized signaling pathways
• binds to many protein, usually by recognition of a phospho-Ser or phosphot-Thr motif
• binding generally results in modulation of activity of the binding partner
• interacts with RGNEF (putative)
• interacts with many nuclear hormone receptors & cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP & THRA

Structure

• homodimer.
• belongs to the 14-3-3 family

Expression

• expressed mainly in the brain & present in other tissues albeit at lower levels

More general terms

• 14-3-3 protein (KCIP-1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7533
• OMIM: https://mirror.omim.org/entry/113508
• UniProt: http://www.uniprot.org/uniprot/Q04917.html