adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; adrenocorticotropin receptor; melanocortin receptor 2; MC2-R (MC2R ACTHR)

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^[1]^[2]^[3]^[4]

Function

receptor for ACTH
activity mediated by G proteins (Gs protein) which activate adenylate cyclase
interacts with FALP/MRAP

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

Expression

melanocytes & corticoadrenal tissue

Pathology

defects in MC2R are the cause of glucocorticoid deficiency type 1

More general terms

melanocortin receptor

Additional terms

adrenocorticotropic hormone; corticotropin; adrenocorticotropin (ACTH)

References

↑ UniProt http://www.uniprot.org/uniprot/Q01718.html
↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=MC2R
↑ Cozza EN et al ACTH increases de novo synthesis of diacylglycerol and translocates protein kinase C in primary cultures of calf adrenal glomerulosa cells. J Steroid Biochem. 1990 Feb;35(2):343-51. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2155356
↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4158

Database

Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4158
OMIM: https://mirror.omim.org/entry/202200
OMIM: https://mirror.omim.org/entry/607397
UniProt: http://www.uniprot.org/uniprot/Q01718.html
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4158

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