melanocortin 2 receptor accessory protein (fat cell-specific low molecular weight protein, fat tissue-specific low MW protein, B27, MRAP, C21orf61, FALP)

Function

• required for MC2R expression in certain cell types
• role in processing, trafficking or function of MC2R (putative)
• role in intracellular trafficking pathways in adipocytes
• interacts with MC2R.

Compartment

• cytoplasm, perinuclear region, cell membrane, endoplasmic reticulum
• concentrated at perinuclear membrane region
• upon insulin stimulation, redistributed into spotty structures throughout cytoplasm
• localizes both to plasma membrane & endoplasmic reticulum

Alternative splicing

named isoforms=4

Expression

• expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary, fat

expressed in adipose tissues

Pathology

• defects in MRAP are a cause of familial glucocorticoid deficiency type 1

More general terms

• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/202200
• UniProt: http://www.uniprot.org/uniprot/Q8TCY5.html