mediator of RNA polymerase II transcription subunit 1; activator-recruited cofactor 205 kD component; ARC205; mediator complex subunit 1; peroxisome proliferator-activated receptor-binding protein; PBP; PPAR-binding protein; thyroid hormone receptor-associated protein complex 220 kD component; trap220; thyroid receptor-interacting protein 2; TR-interacting protein 2; TRIP-2; vitamin D receptor-interacting protein complex component DRIP205; p53 regulatory protein RB18A (MED1, ARC205, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2)

Function

• component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes
• phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability & promote entry into the nucleolus
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with GATA1 & YWHAH (putative)
• specifically interacts with a number of nuclear receptors (ligand-dependent) including AR, ESR1, ESR2, PPARA, PPARG, RXRA, RXRG, THRA, THRB & VDR
• interacts with CTNNB1, GABPA, GLI3, PPARGC1A & TP53
• binds DNA

Structure

• belongs to the mediator complex subunit 1 family

Compartment

• nucleus
• a subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

More general terms

• thyroid hormone receptor interacting protein (TRIP)
• phosphoprotein
• DNA-binding protein

Component of

• thyroid hormone receptor associated protein complex (TRAP)
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5469
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5469
• OMIM: https://mirror.omim.org/entry/604311
• UniProt: http://www.uniprot.org/uniprot/Q15648.html