A disintegrin & metalloproteinase domain 1 (ADAM1, ADAMDEC1)

Function

• role in control of immune response & during pregnancy (putative)

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• contains 1 disintegrin domain
• contains 1 peptidase M12B domain

Compartment

secreted (putative)

Expression

• expressed highly in the small intestine & appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen & very weakly in the bone marrow
• predominantly expressed in dendritic cells of the germinal center
• weakly expressed in monocyte & highly expressed in macrophage
• absent in immature endritic cells
• induced during endritic cell maturation & up-regulated in response to T-cell signals
• in macrophage, up-regulated by lipopolysaccharide (LPS)
• up-regulated by 1,25-dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage

More general terms

• ADAM protease

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8759
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27299
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27299
• OMIM: https://mirror.omim.org/entry/606393
• UniProt: http://www.uniprot.org/uniprot/O15204.html