A disintegrin & metalloproteinase domain 19; meltrin-beta; metalloprotease & disintegrin dendritic antigen marker; MADDAM (ADAM19, MLTNB, FKSG34)

Function

• role in proteolytic processing of beta neuregulin isoforms
• possible regulatory role in glial cells
• also cleaves alpha-2 macroglobulin
• may be involved in osteoblast differentiation &/or osteoblast activity in bone
• interacts with SH3PXD2A
• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from the Zn+2 upon the activation- peptide release activates the enzyme
• contains 1 disintegrin domain
• contains 1 EGF-like domain
• contains 1 peptidase M12B domain

Compartment

membrane

Alternative splicing

named isoforms=2; A, B

Expression

• expressed in many normal organ tissues & several cancer cell lines
• induced by calcitriol in monocytes

More general terms

• ADAM protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8728
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8728
• OMIM: https://mirror.omim.org/entry/603640
• UniProt: http://www.uniprot.org/uniprot/Q9H013.html