A disintegrin & metalloproteinase domain 15; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 15; MDC-15; metalloprotease RGD disintegrin protein; metargidin (ADAM15, MDC15)
Jump to navigation
Jump to search
Function
- may be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation
- interacts with ITAGV-ITGB3 (vitronectin receptor), PACSIN3 & SNX9; PACSIN3 & SNX9 preferentially bind the precursor but not the processed form of ADAM15, suggesting that the interaction occurs in a secretory pathway compartment prior to the medial Golgi (putative)
- interacts specifically with Src family proteins
- interacts with SH3PXD2A
- cytoplasmic domain interacts with SH3 domain of endophilin 1 & sorting nexin 9 (putative)
- interacts with MAD2L2
- precursor is cleaved by a furin endopeptidase
- phosphorylation increases association with PTKs
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure
- desintegrin domain binds to integrin alphaV-beta3
- conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
- dissociation of Cys from Zn+2 upon the activation- peptide release activates the enzyme
- contains 1 disintegrin domain
- contains 1 EGF-like domain
- contains 1 peptidase M12B domain
Compartment
membrane
Expression
- ubiquitously expressed
- constitutively expressed in cultured endothelium & smooth muscle.
- expressed in chondrocytes
Pathology
- overexpressed in atherosclerotic lesions but not normal aorta