protein kinase C & casein kinase substrate in neurons protein 3; SH3 domain-containing protein 6511; endophilin I (PACSIN3)

Function

• may play a role in vesicle formation & transport
• phosphorylated by casein kinase 2 (CK2) & protein kinase C (PKC) (probable)
• homo- & hetero-aggregates with other PACSINs
• binds dynamin-1, synaptojanin, synapsin-1 & the neural Wiskott-Aldrich syndrome protein (N-WASP)
• also interacts with MDC9 & MDC15

Structure

• belongs to the PACSIN family
• contains 1 FCH domain
• contains 1 SH3 domain

Compartment

• cytoplasm
• cell membrane; peripheral membrane protein; cytoplasmic side
• detected at the inner aspect of the plasma membrane in cells or myotubes

Expression

• expressed in heart & skeletal muscle, lung, kidney, adrenal gland & placenta

More general terms

• protein kinase c & casein kinase substrate in neurons protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29763
• OMIM: https://mirror.omim.org/entry/606513
• UniProt: http://www.uniprot.org/uniprot/Q9UKS6.html