A disintegrin & metalloproteinase domain 9; metalloprotease/disintegrin/cysteine-rich protein 9; myeloma cell metalloproteinase; meltrin gamma (ADAM9, KIAA0021, MCMP, MDC9, MLTNG)

Function

• probable Zn+2 protease
• may mediate cell-cell or cell-matrix interactions
• isoform 2 displays alpha-secretase activity for APP
• interacts with MAD2L2
• cytoplasmic domain interacts with SH3 domain of endophilin 1 & protein kinase C

Cofactor: binds 1 Zn+2 per subunit (probable)

Structure

• contains 1 disintegrin domain
• contains 1 EGF-like domain
• contains 1 peptidase M12B domain

Compartment

• isoform 1: cell membrane
• isoform 2: secreted

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed in chondrocytes
• highest expression of isoform 2 found in liver & heart

Notes

has sometimes been referred to as ADAM-12

More general terms

• ADAM protease
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8754
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8754
• OMIM: https://mirror.omim.org/entry/602713
• UniProt: http://www.uniprot.org/uniprot/Q13443.html