A disintegrin & metalloproteinase domain 11; metalloproteinase-like, disintegrin-like, & cysteine-rich protein (ADAM11, MDC)

Function

• probable ligand for integrin in the brain
• non catalytic metalloprotease-like protein
• precursor is cleaved by a furin endopeptidase

Structure

• conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor
• contains 1 disintegrin domain
• contains 1 EGF-like domain
• contains 1 peptidase M12B domain

Compartment

membrane

Alternative splicing

named isoforms=2

• long (MDC-769)
• short (MDC-524)

Expression

• expressed predominantly in brain
• slightly detected or not at all in other tissues

Pathology

• rearrangements occur in breast cancer & ovarian cancer which involve multiple exons & disrupt the coding region

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• ADAM protease

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4185
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4185
• OMIM: https://mirror.omim.org/entry/155120
• UniProt: http://www.uniprot.org/uniprot/O75078.html