A disintegrin & metalloproteinase domain 30 (ADAM30)

Function

• may be involved in spermatogenesis & fertilization

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from Zn+2 upon the activation- peptide release activates the enzyme
• contains 1 disintegrin domain
• contains 1 EGF-like domain
• contains 1 peptidase M12B domain

Compartment

membrane

Alternative splicing

named isoforms=2; alpha, beta

Expression

expressed specifically in testis

More general terms

• ADAM protease
• glycoprotein
• testis-specific protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11085
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11085
• OMIM: https://mirror.omim.org/entry/604779
• UniProt: http://www.uniprot.org/uniprot/Q9UKF2.html