disintegrin & metalloproteinase domain-containing protein 5; transmembrane metalloproteinase-like, disintegrin-like, & cysteine-rich protein II; tMDC II (ADAM5P, TMDC2)
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Function
- non catalytic metalloprotease-like protein
Structure
- contains 1 disintegrin domain
- contains 1 EGF-like domain
Alternative splicing
named isoforms=7
Expression
highly expressed in testis
Notes
- initially thought to code for proteins of 42-72 amino acids & was therefore classified as a pseudogene
- not expected to have protease activity[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q6NVV9.html
- ↑ 2.0 2.1 Frayne J, Dimsey EA, Jury JA, Hall L. Transcripts encoding the sperm surface protein tMDC II are non-functional in the human. Biochem J. 1999 Aug 1;341 ( Pt 3):771-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10417343