A disintegrin & metalloproteinase domain 33 (ADAM33)

Function

• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
• contains 1 disintegrin domain
• contains 1 EGF-like domain
• contains 1 peptidase M12B domain

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in all tissues, except liver, with high expression in placenta, lung, spleen & veins

Pathology

• defects in ADAM33 may be a cause of susceptibility to asthma

More general terms

• ADAM protease
• phosphoprotein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80332
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80332
• OMIM: https://mirror.omim.org/entry/607114
• UniProt: http://www.uniprot.org/uniprot/Q9BZ11.html