K-ras 2 proto-oncogene protein (GTPase KRas, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, KRAS, KRAS2, RASK2)

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Function

Structure

belongs to the small GTPase superfamily. Ras family

Compartment

cell membrane, lipid-anchor, cytoplasmic side

Alternative splicing

named isoforms=2 isoforms 2A & 2B differ in the C-terminal region encoded by two alternative exons (IVA & IVB) variant in position: 153:D->V (in CFC syndrome)

Pathology

More general terms

More specific terms

References

  1. UniProt http://www.uniprot.org/uniprot/P01116.html
  2. Atlas of genetics & cytogenetics in oncology & Haematology http://atlasgeneticsoncology.org/genes/KRASID91.html
  3. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=KRAS
  4. SHMPD; Note: The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=KRAS
  5. 5.0 5.1 Scholl C et al Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 2009 May 29; 137:821 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19490892

Database