PH domain leucine-rich repeat protein phosphatase; suprachiasmatic nucleus circadian oscillatory protein; hSCOP, (PHLPP, PHLPP1, KIAA0606, PLEKHE1, SCOP)
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Function
- mediates dephosphorylation of Ser-473 of AKT1
- triggers apoptosis & suppression of tumor growth
- negative regulator of K-Ras signaling in the membrane rafts.
- insensitive to okadaic acid
Compartment
cytoplasm, membrane
Expression
Pathology
- down-regulated in colon cancer & glioblastoma cell lines