juvenile myelomonocytic leukemia

Epidemiology

• children
• ~30% of childhood cases of myelodysplastic syndrome & 2% of leukemia

Pathology

• leukocytosis with tissue infiltration

Genetics

• associated with germline mutations in neurofibromin gene
• other implicated genes KRAS, NRAS, PTPN11

Laboratory

• leukocytosis
• in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor (GM-CSF)

More general terms

• AML-M4; acute myelomonocytic leukemia

Database

• OMIM: https://mirror.omim.org/entry/607785