N-ras proto-oncogene protein (neuroblastoma ras, NRAS)
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Introduction
Neuroblastoma ras. One of 4 'true' ras proteins [p21ras].
Function
- Ras proteins bind GDP/GTP & possess intrinsic GTPase activity
- alternate between an inactive form bound to GDP & an active form bound to GTP
- activated by a guanine nucleotide-exchange factor (GEF)
- inactivated by a GTPase-activating protein (GAP)
- palmitoylated by the ZDHHC9-GOLGA7 complex
- a continuous cycle of de- & re-palmitoylation regulates rapid exchange between plasma membrane & Golgi
- p21ras binds to & activates raf1 protein probably in association with other proteins; raf1 activates MEK which in turn activates MAP kinases
Structure
belongs to the small GTPase superfamily, Ras family
Compartment
- cell membrane, lipid-anchor, cytoplasmic side
- Golgi apparatus membrane lipid-anchor
- shuttles between the plasma membrane & the Golgi apparatus
Pathology
- defects in NRAS are a cause of
- mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells & are implicated in a variety of human tumors
More general terms
References
- ↑ Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209
- ↑ UniProt http://www.uniprot.org/uniprot/P01111.html
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/NRASID92.html
- ↑ Wikipedia; Note: RAS proteins entry http://en.wikipedia.org/wiki/RAS_proteins