zinc finger protein 379; palmitoyltransferase ZDHHC9; zinc finger DHHC domain-containing protein 9; DHHC-9; DHHC9; zinc finger protein 380 (ZDHHC9, CXorf11, ZDHHC10, ZNF379, ZNF380, CGI-89, UNQ261/PRO298)

Function

• the ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS & NRAS

interacts with GOLGA7

palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

Structure

• the DHHC domain is required for palmitoyltransferase activity
• belongs to the DHHC palmitoyltransferase family ERF2/ZDHHC9 subfamily
• contains 1 DHHC-type Zn+2 finger

Compartment

• endoplasmic reticulum membrane;
• Golgi membrane

Expression

• highly expressed in kidney, skeletal muscle, brain, lung & liver
• absent in thymus, spleen & leukocytes

Pathology

• defects in ZDHHC9 are the cause of mental retardation syndromic X-linked ZDHHC9-related (MRXSZ)

More general terms

• S-palmitoyl transferase
• zinc finger protein
• transmembrane 4 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51114
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51114
• OMIM: https://mirror.omim.org/entry/300646
• OMIM: https://mirror.omim.org/entry/300799
• UniProt: http://www.uniprot.org/uniprot/Q9Y397.html