Butyrate response factor 2 (protein TIS11D, EGF-response factor 2, ERF-2) (ZFP36L2 BRF2 ERF2 RNF162C TIS11D)

Function

• probable regulatory protein involved in regulating the response to growth factors
• RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence.
• binds to the class 2 AU-rich element (ARE) in the 3'-UTR of target mRNAs & promotes their deadenylation & degradation

Structure

contains 2 C3H1-type zinc fingers

Compartment

nucleus (putative)

More general terms

• nuclear protein
• zinc finger protein
• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P47974.html