Zn finger C3H1-type

Function

• interacts with the 3'-untranslated region of mRNAs

Structure

• conserved cysteine-histidine arrangement, C-x(8)-C-x(5)-C-x(3)-H

Expression

• present in many eukaryotic proteins from yeast to mammals
• very often present in two copies
• proteins known to contain a C3H1-type zinc finger include:
  • mammalian tristetraprolin proteins
  • eukaryotic TIS/CTH family
  • Cpsf4
  • makorin-1, makorin-3 (ZNF127)

More general terms

• Zinc finger (cysteine finger)