cleavage & polyadenylation specificity factor subunit 4; cleavage & polyadenylation specificity factor 30 kD subunit; CPSF 30 kD subunit; NS1 effector domain-binding protein 1; Neb-1; No arches homolog (CPSF4 CPSF30 NAR NEB1)

Function

• component of the CPSF complex
• binds RNA polymers with preference for poly(U)
• interacts with FIP1L1
• association with influenza A virus NS1 blocks processing of pre-mRNAs & prevents nuclear export of host cell mRNAs

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• protein subunit
• zinc finger protein
• phosphoprotein

Component of

• cleavage & polyadenylation specificity factor (CPSF) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10898
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10898
• OMIM: https://mirror.omim.org/entry/603052
• UniProt: http://www.uniprot.org/uniprot/O95639.html