antoxidant-response element (ARE)

From Aaushi
Jump to navigation Jump to search
[1][2]

Introduction

Mediates transcription of genes in cells exposed to oxidative stress via the transcription factor Nrf2. Genes encoding antioxidant enzymes as well as phase 2 detoxification enzymes appear to contain the ARE. Activation of genes containing the ARE is induced by electrophilic compounds & phenolic antioxidants. Nrf2 upregulates genes containing the ARE perhaps as a hetero- dimer with small maf proteins lacking the transcriptional activation domain[1]. maf proteins including c-maf & small mafs (G-maf) appear to down-regulate genes containing the ARE[2].

More general terms

References

  1. ↑ 1.0 1.1 Nguyen T et al Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol. 2003;43:233-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12359864
  2. ↑ 2.0 2.1 Dhakshinamoorthy S & Jaiswal AK c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction. Oncogene 21:5301, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12149651
Retrieved from "https://aaushi.info/w/index.php?title=A144094&oldid=1160996"