transcription factor Maf; maf proto-oncogene protein; v-maf musculoaponeurotic fibrosarcoma oncogene homolog; proto-oncogene protein c-maf (MAF)

Function

• downregulates antioxidant-response element mediated gene expression
• upregulates Maf recognition element (MARE) mediated p53 gene expression

Structure

• belongs to the bZIP family, Maf subfamily
• contains 1 bZIP domain
• may contain transcriptional activation domain
• may be classified as large Maf

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Pathology

• chromosomal translocation t(14;16)(q32.3;q23) involving MAF with an IgH locus is found in some forms of multiple myeloma
• defects in MAF are the cause of
  • juvenile-onset pulverulent cataract
  • congenital cerulean cataract 4

More general terms

• maf family protein
• proto oncogene protein

Database

• OMIM: https://mirror.omim.org/entry/177075
• UniProt: http://www.uniprot.org/uniprot/O75444.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4094