LIM domain-containing protein 2 (LIMD2)

Function

• bound directly to the kinase domain of integrin-linked kinase (ILK) near the active site, strongly activated ILK kinase activity

Structure

contains 1 LIM Zn+2-binding domain

Expression

overexpressed in metastatic lesions but absent in the matched primary tumor

Pathology

• may play a role in metastasis via activation of ILK

More general terms

• other protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80774
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80774
• UniProt: http://www.uniprot.org/uniprot/Q9BT23.html