engulfment & cell motility protein 2 (CED-12 homolog A, hCED-12A, ELMO2, CED12A, KIAA1834)

Function

• role in cytoskeletal rearrangements required for phagocytosis of apoptotic cells & cell motility
• acts in assocation with DOCK1 & CRK
• interacts with the SH3-domain of DOCK1 via its SH3-binding site
• component of a complex with DOCK1 & RAC1
• component of a complex with DOCK1 & CRK isoform CRK-II
• may enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1

Structure

• contains 1 ELMO domain
• contains 1 PH domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• widely expressed, higher expression in skeletal muscle, kidney, placenta

More general terms

• engulfment & cell motility protein (ELMO)

Database

• OMIM: https://mirror.omim.org/entry/606421
• UniProt: http://www.uniprot.org/uniprot/Q96JJ3.html