G-protein coupled receptor 2 (GPR2)

Function

• receptor for chemokines SCYA27 & SCYA28
• transduces a signal by increasing intracellular Ca+2
• stimulates chemotaxis in a pre-B cell line

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed adult testis, small intestine, fetal lung, fetal kidney > spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid & spinal cord
• expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells
• detected in T-cells & in skin-derived Langerhans cells

More general terms

• CC chemokine receptor
• phosphoprotein

Additional terms

• atypical chemokine receptor 2; C-C chemokine receptor 10; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine receptor CCR-9; chemokine-binding protein 2; chemokine-binding protein D6 (ACKR2, CCBP2, CCR10, CMKBR9, D6)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2826
• OMIM: https://mirror.omim.org/entry/600240
• UniProt: http://www.uniprot.org/uniprot/P46092.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2826