C-C motif chemokine 28; mucosae-associated epithelial chemokine; MEC; protein CCK1; small-inducible cytokine A28 (CCL28, SCYA28)

Function

• chemotactic activity for resting CD4 cells, CD8 T-cells & eosinophils
• binds to CCR3 & CCR10 & induces Ca+2 mobilization (dose-dependent)

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• preferentially expressed by epithelial cells of diverse tissues including normal & pathological colon, salivary gland, mammary gland, trachea & rectum
• also found in prostate, spleen, thyroid, psoriasis skin & in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach & normal skin

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56477
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56477
• OMIM: https://mirror.omim.org/entry/605240
• UniProt: http://www.uniprot.org/uniprot/Q9NRJ3.html