low density lipoprotein (LDL) receptor related protein (LRP) 2 (LRP2, glycoprotein 330, gp330)

Function

• acts together with cubilin to mediate HDL endocytosis (putative)
• may participate in regulation of parathyroid hormone & parathyroid-hormone-related protein release
• binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type 1 complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin & Ca+2
• forms a multimeric complex together with a receptor-associated protein (RAP)
• binds to ankyrin-repeat family A protein 2 (ANKRA2)
• interacts with LRP2BP

Structure

• belongs to the LDLR family
• contains 17 EGF-like domains
• contains 36 LDL-receptor class A domains
• contains 37 LDL-receptor class B repeats

Compartment

membrane

Expression

absorptive epithelia, including renal proximal tubules

Pathology

• defects in LRP2 are the cause of Donnai-Barrow syndrome

More general terms

• low-density lipoprotein (LDL) receptor related protein (LRP)
• glycoprotein

Additional terms

• LRP2-binding protein (megalin-binding protein, MegBP, LRP2BP, KIAA1325)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4036
• OMIM: https://mirror.omim.org/entry/222448
• OMIM: https://mirror.omim.org/entry/600073
• UniProt: http://www.uniprot.org/uniprot/P98164.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4036