ankyrin repeat family A protein 2 (RFXANK-like 2, ANKRA2, ANKRA)

Function

• endocytosis
• links megalin to cytoskeleton or endocytic machinery
• interacts with cytoplasmic tail of LRP2/megalin, HDAC4, HDAC5, & HDAC9
• all these interactions occur via recognition of a PxLPxI/L motif
• interacts with AHRR
• interacts with NEK6

Structure

• 3 central ANK repeats mediate binding to the PxLPxI/L motif of interactors
• contains 5 ANK repeats

Compartment

• cytoplasm, cytoskeleton
• peripheral membrane

More general terms

• ankyrin repeat domain protein (ANKRD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57763
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57763
• OMIM: https://mirror.omim.org/entry/605787
• UniProt: http://www.uniprot.org/uniprot/Q9H9E1.html