low-density lipoprotein receptor; LDL receptor; apoB/E receptor (LDLR)
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Function
- binds LDL, the major cholesterol-carrying lipoprotein of plasma, & transports it into cells by endocytosis
- in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits
- the LDL receptor binds 2 ligands, apo B-100 & apo-E, apolipoproteins with completely different sequences
- interacts with LDLRAP1
- interacts with SNX17
Structure
- N- & O-glycosylated
- belongs to the LDLR family
- contains 3 EGF-like domains
- contains 7 LDL-receptor class A domains
- contains 6 LDL-receptor class B repeats
- Ser/Asp/Glu triplet at C-terminal end of L-module is important for ligand-binding
Compartment
membrane, clathrin-coated pit
Expression
Pathology
- defects in LDLR are the cause of familial hypercholesterolemia)
- interacts with HIV-1 Tat in case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells
- interacts with HCV E1/E2 heterodimer
Notes
- also see apo B-48 receptor
More general terms
More specific terms
Additional terms
- apolipoprotein B-48 receptor; apoB48 receptor; apoB-48R (APOB48R, APOBR)
- CD36; platelet glycoprotein 4; platelet glycoprotein IV; GPIV; glycoprotein IIIb; GPIIIB; leukocyte differentiation antigen CD36; PAS IV; PAS-4; platelet collagen receptor; fatty acid translocase; FAT; Thrombospondin receptor (GP3B, GP4)
- low density lipoprotein (LDL, beta-lipoprotein)
- low-density lipoprotein (LDL) receptor related protein (LRP)
References
- ↑ Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell. 1991 Jan 25;64(2):281-302. Review. Erratum in: Cell 1991 May 31;65(5):following 914. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1846320
- ↑ Baron M, Norman DG, Campbell ID. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053133
- ↑ Primary Hyperlipoproteinemias, Steiner & Shafrir (eds), McGraw Hill, NY, 1991, pg 31
- ↑ Yamamoto et al Cell 39:27 1984 (cDNA sequence)
- ↑ UniProt http://www.uniprot.org/uniprot/P01130.html
- ↑ LDLR; Note: LDLR mutation database http://www.ucl.ac.uk/fh/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=LDLR
- ↑ SHMPD; The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LDLR