oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; lectin-type oxidized LDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-like oxLDL receptor 1; LOX-1; hLOX-1 (OLR1, LOX1)

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Function

mediates recognition, internalization & degradation of oxidized low density lipoprotein (oxLDL) by vascular endothelial cells
binding of oxLDL induces the activation of NF-kappa-B via
- production of intracellular reactive oxygen
- reduction of nitric oxide (NO) release
- monocyte adhesion
- apoptosis
receptor for the HSP70 protein
- antigen cross-presentation to naive T-cells in dendritic cells
leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation
receptor for
- advanced glycation end products (AGE)
- activated platelets
- monocytes
- apoptotic cells
- Gram-negative & Gram-positive bacteria
interacts with HSP70

homodimer, disulfide-linked
may form a hexamer
N-glycosylated
intrachain disulfide-bonds prevent N-glycosylation at some sites
contains 1 C-type lectin domain; C-type lectin domain mediates the recognition & binding of oxLDL
cytoplasmic region is required for subcellular sorting on the cell surface

binding of oxLDL induces pro-atherogenic cellular response
may amplify oxLDL-induced vascular dysfunction
defects in OLR1 may be a cause of:
- susceptibility to myocardial infarction
- susceptibility to Alzheimer disease (AD) (controversial)