oxidized low density lipoprotein (oxidized LDL, oxLDL)
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Function
- recognized & degraded by OLR1
- recognized by C-type lectin domain of OLR1
- may mediate response to fluid shear stress
Pathology
- marker of atherosclerosis
- induces vascular endothelial cell activation & dysfunction pro-inflammatory responses, pro-oxidative conditions & apoptosis
- oxidized choline glycerophospholipids activate platelet CD36, promote platelet activation, impair endothelial function & increase foam cell concentration within atherosclerotic plaques[2]
Laboratory
More general terms
Additional terms
- oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; lectin-type oxidized LDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-like oxLDL receptor 1; LOX-1; hLOX-1 (OLR1, LOX1)
- oxysterol; hydroxysterol
References
- ↑ OMIM https://mirror.omim.org/entry/600168
- ↑ 2.0 2.1 Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR, Chen J, Zhang R, Silverstein RL, Hazen SL. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med. 2007 Sep;13(9):1086-95. Epub 2007 Aug 26. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17721545
Jackson SP, Calkin AC. The clot thickens-oxidized lipids and thrombosis. Nat Med. 2007 Sep;13(9):1015-6. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/17828215 <Internet> http://jama.ama-assn.org/cgi/content/full/297/5/499