lactotransferrin; lactoferrin; talalactoferrin; contains: kaliocin-1; lactoferroxin-A; lactoferroxin-B; lactoferroxin-C (LTF, LF)

Function

• transferrins are iron binding transport proteins which can bind two Fe+3 ions in association with the binding of an anion, usually bicarbonate
• lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration
• lactoferroxins A, B & C have opioid antagonist activity
• lactoferroxin A shows preference for opioid mu-receptors
• lactoferroxin B & C have somewhat higher degrees of preference for opioid kappa-receptors than for opioid mu-receptors
• the lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions
  • this function contributes to the antimicrobial activity
  • preferential at -Arg-Ser-Arg-Arg-|- & -Arg-Arg-Ser-Arg-|-, & of Z-Phe-Arg-|-aminomethylcoumarin

Structure

• monomer
• belongs to the transferrin family
• contains 2 transferrin-like domains

Compartment

secreted

Pathology

• found associated with amyloid deposits in Alzheimer's disease

More general terms

• glycoprotein
• metalloprotein
• milk protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4057
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4057
• OMIM: https://mirror.omim.org/entry/150210
• OMIM: https://mirror.omim.org/entry/245480
• UniProt: http://www.uniprot.org/uniprot/P02788.html