kappa opioid receptor; KOR-1 (OPRK1 OPRK)
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Function
- receptor for dynorphins
- inhibits neurotransmitter release by reducing Ca+2 currents & increasing K+ conductance
- may play a role in arousal & regulation of autonomic & neuroendocrine functions
- implication of dynorphins in LTP suggests OPRK1 may be involved as well
- interacts with SLC9A3R1
- interacts with GABARAPL1
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P41145.html
- ↑ Wikipedia; Note: Kappa opioid receptor entry http://en.wikipedia.org/wiki/Kappa_opioid_receptor
- ↑ Weisskopf MG, Zalutsky RA, Nicoll RA. The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation. Nature. 1993 Apr 1;362(6419):423-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8096624
- ↑ Reisine T, Bell GI. Molecular biology of opioid receptors. Trends Neurosci. 1993 Dec;16(12):506-10. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7509520