gamma-aminobutyric acid receptor-associated protein-like 1; early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; glandular epithelial cell protein 1; GEC-1 (GABARAPL1, GEC1)

Function

• increases cell-surface expression of opioid kappa receptor through facilitating anterograde intracellular trafficking of the receptor
• interacts with GABRG2 & beta-tubulin (putative)
• interacts with OPRK1
• interacts with TP53INP1 & TP53INP2

Structure

belongs to the MAP1 LC3 family

Compartment

• cytoplasm, cytoskeleton
• endoplasmic reticulum, Golgi (putative)
• cytoplasmic vesicle, autophagosome

Expression

• ubiquitous
• expressed at very high levels brain, heart, peripheral blood leukocytes, liver, kidney, placenta & skeletal muscle
• expressed at very low levels in thymus, small intestine

More general terms

• cytoskeletal protein

Additional terms

• GABA-A receptor
• gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; MM46 (GABARAP, FLC3B, HT004)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23710
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23710
• OMIM: https://mirror.omim.org/entry/607420
• UniProt: http://www.uniprot.org/uniprot/Q9H0R8.html