microtubule-associated protein 1A; MAP-1A; proliferation-related protein p80; contains: MAP1 light chain LC2 (MAP1A MAP1L)

Function

• structural protein involved in the filamentous cross- bridging between microtubules & other skeletal elements
• phosphorylated upon DNA damage, probably by ATM or ATR
• Ser may be phosphorylated by cAMP kinase
• LC2 is generated from MAP1A by proteolytic processing
• 3 different light chains, LC1, LC2 & LC3, can associate with MAP1A & MAP1B proteins
• interacts with TIAM2
• interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4

Structure

• the basic region (lysine-rich region) containing the repeats may be responsible for binding of MAP1A to microtubules
• belongs to the MAP1 family

Expression

brain

More general terms

• microtubule-associated protein (MAP)

Database

• OMIM: https://mirror.omim.org/entry/600178
• UniProt: http://www.uniprot.org/uniprot/P78559.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4130