microtubule-associated protein 1B; MAP-1B; microtubule-associated protein 5; contains: MAP1 light chain LC1 (MAP1B)
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Function
- function essentially
- phosphorylated MAP1B may play a role in cytoskeletal changes that accompany neurite extension
- may bind to at least two tubulin subunits in the polymer, & this bridging of subunits might be involved in nucleating microtubule polymerization & in stabilizing microtubules
- MAP1 light chain LC1 is generated from MAP1B by proteolytic processing
- phosphorylated upon DNA damage, probably by ATM or ATR
- phosphorylated form involved in neurite outgrowth
- 3 different light chains, LC1, LC2 & LC3, can associate with MAP1A & MAP1B proteins
- LC1 interacts with the amino-terminal region of MAP1B
- interacts with ANP32A & TIAM2
- interacts (via C-terminus) with GAN (via kelch domains)
Structure
- highly basic region with many copies of the sequence KKEE & KKEI/V, repeated but not at fixed intervals, responsible for the binding of MAP1B to microtubules
- belongs to the MAP1 family
Expression
Pathology
- phosphorylated form found in neurofibrillary tangles
More general terms
References
- ↑ Hasegawa M et al Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease. Neuron 1990 Jun;4(6):909-18 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2361014
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4131
- ↑ UniProt http://www.uniprot.org/uniprot/P46821.html