acidic leucine-rich nuclear phosphoprotein 32 family member A; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; acidic nuclear phosphoprotein pp32; leucine-rich acidic nuclear protein; Lanp; HLA-DR-associated protein I; PHAPI; mapmodulin (ANP32A, C15orf1, LANP, MAPM, PHAP1)

Function

• implicated in a number of cellular processes, including
  • proliferation
  • differentiation
  • caspase-dependent & caspase-independent apoptosis
  • suppression of transformation (tumor suppressor)
  • inhibition of protein phosphatase 2A
  • regulation of mRNA trafficking & stability in association with ELAVL1
  • inhibition of acetyltransferases as part of the INHAT complex (inhibitorof histone acetyltransferases)
• role in E4F1-mediated transcriptional repression
• phosphorylated on Ser
• some Glu are glycylated by TTLL8
  • occurs exclusively on Glu & results in a Gly chain on the gamma-carboxyl group (putative)
• component of the SET complex
• interacts with ATXN1/SCA1
• interacts with MAP1B (putative)
• interacts with ELAVL1
• part of the INHAT (inhibitor of histone acetyltransferases) complex
• interacts with E4F1

Structure

• the N-terminus is blocked
• belongs to the ANP32 family
• contains 4 LRR repeats (leucine-rich repeats)

Compartment

• nucleus, cytoplasm
• shuttles between nucleus & cytoplasm

Expression

• expressed in all tissues tested
• expressed in kidney & skeletal muscle > brain, placenta & pancreas > lung
• found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus & thalamus), with highest levels in amygdala

More general terms

• nuclear protein
• leucine-rich repeat-containing protein (LRRC)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P39687.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8125
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8125
• OMIM: https://mirror.omim.org/entry/600832