Na+/H+ exchange regulatory cofactor NHE-RF1; NHERF-1; Ezrin-radixin-moesin-binding phosphoprotein 50; EBP50; regulatory cofactor of Na+/H+ exchanger; Na+-hydrogen exchanger regulatory factor 1; solute carrier family 9 isoform A3 regulatory factor 1 (SLC9A3R1, NHERF, NHERF1)

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Function

scaffold protein
connects plasma membrane proteins with members of the ezrin/moesin/radixin family & thereby helps to link them to the actin cytoskeleton & to regulate their surface expression
necessary for recycling of internalized ADRB2
first known to play a role in the regulation of the activity & subcellular location of SLC9A3
necessary for cAMP-mediated phosphorylation & inhibition of SLC9A3.
may enhance Wnt signaling
may participate in HTR4 targeting to microvilli
interacts with MCC
phosphorylated on Ser
homodimer, & heterodimer with SLC9A3R2
binds the N-termini of EZR, RDX & MSN. binds the C-termini of PDGFRA, PDGFRB, ADRB2, NOS2 & CFTR. binds ARHGAP17, EPI64, GNB2L1, OPRK1, GNAQ, CTNNB1 & PLCB3
binds PDZK1 (putative)
interacts with CLCN3
binds the C-terminus of PAG1
in resting T- cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation
forms a complex with CFTR & SLC4A7
forms a complex with SLC4A7 & ATP6V1B1
interacts with TRPC4 (via the PDZ-binding domain)
directly interacts with HTR4 (putative)
interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is not detected in glomerular epithelium cells
interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); the interaction occurs early in the secretory pathway & is necessary for its apical membrane sorting (putative)