moesin; membrane-organizing extension spike protein (MSN)

Function

• role in connections of major cytoskeletal structures to the plasma membrane
• associated with actin/integrin focal contacts
• phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures (putative)
• in resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (putative)
• binds SLC9A3R1

Structure

contains 1 FERM domain

Compartment

• cell membrane
• peripheral membrane protein cytoplasmic side (putative)
• cytoplasm, cytoskeleton
• apical cell membrane
• cell projection, microvillus membrane
• phosphorylated form is enriched in microvilli-like structures at apical membrane (putative)

Expression

expressed in all tissues & cultured cells studied

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P26038.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4478
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4478
• OMIM: https://mirror.omim.org/entry/309845